Bitstream - radiotherapy


Identity ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS ICD-Morpho 9807/3 Mixed phenotype acute leukaemia with t(v;11q23); MLL rearranged ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS ICD-Morpho 9837/3 T lymphoblastic leukaemia/lymphoma ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS ICD-Morpho 9920/3 Therapy-related myeloid neoplasms ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable Atlas_Id 1030 Clinics and Pathology Disease de novo and therapy related leukaemias; acute myeloid leukaemia (AML) and acute lymphocytic leukaemia (ALL) grossly represent half cases each; myelodysplasia (MDS) in the remaining 5%; biphenotypic leukaemia at times (likely to be more frequent with more investigations); 11q23 rearrangements in treatment related leukaemias (5-10% of 11q23 cases) are found mainly following a treatment with anti-topoisomerase II, or an intercalating topoisomerase II inhibitor, but also after alkylating agents treatment and/or radiotherapy; the prior cancer is variable. Phenotype / cell stem origin AML: M5a in half cases, M4 (20%), M1 or M5b (10% each), M2 (5%); ALL: B-cell mostly, L1 or L2, CD19+ in 60% of B-ALL cases, CD10+ 35%; T-ALL in rare cases (


Bitstream - RadiotherapyBitstream - Radiotherapy

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